The problem may be one of opportunity missed with respect to growth and development. While patients can be treated at any age, those with available growth may enjoy a substantial advantage. For some patients, early treatment may prevent the need for jaw surgery, extraction of permanent teeth, or fracture of protruded incisors. Early treatment may also aid in psychological development that is appearance-related. Most harmful oral habits respond best to early treatment. A patient referred in the mixed dentition may also benefit from space management and guidance of eruption.